Memory Management

Hi there, I am working on a game like "Double Dragon". I thing to do it in 16 bpp, but it will have a lot of graphics (many guys, many movements, etc). Be cause that, I would like to read opinions about how to manage the graphics memory (if I need to do the background with tiles, etc) And if you know some sources or examples of double dragon clones, it will be wonderful. Thank in advance Cheers, Dr CRS