Creating many spriteSheets with same Texture2D

You would have to create a Sprite Map in some format (XML is a good choice). This map would define the location and size of each frame of each animation that's in your spritesheet. This gives your animations and spritesheets more flexibility as you don't need to follow a strict size/placement/number for each frame. In addition you can easily re-use sprites during animations.

So an example spritesheet map:

<Object name="Enemy1">
<Sprites>
<Image id="1" x="5" y="5" height="64" width="64"/>
<Image id="2" x="69" y="69" height="102" width="50"/>
</Sprites>

<Animations>
<Animation name="attack" fps="30" numFrames="3" loop="no">
<Frame sourceID="1"/>
<Frame sourceID="2"/>
<Frame sourceID="1"/>
</Animation>

<Animation name="Idle" fps="30" numFrames="1" loop="yes">
<Frame sourceID="1"/>
</Animation>

</Animations>
</Object>


A while ago I was using HGE game engine and they have a custom resource script that they use to load your resources. Maybe if you take a look at their format you would get an idea how to do yours: http://hge.relishgames.com/doc/index.html, choose "hgeResourceManager" on the left menu and then "Resource script" from the related information on that page.

I've played around a little with this tool for making my sprite sheets and plan in the coming weeks to integrate it's XML layout into my game content loader.

http://www.gamedev.net/topic/620583-the-ultimate-texture-atlas-tool/

Thx for the replies!
I figured out a way to do this by just creating a big spritesheet and jump between different rows of the sheet, with Points. Works great