Player / Board Interaction with Python

I want to make a board game with Python. The gameplay design is done, and the board and pieces are saved as .png files. I have some experience with Python, but I don't know much about using it through a graphical interface.

My Problem: I want stuff to happen when the player takes their mouse and clicks on a spot on the board.

Your help would be greatly appreciated.

Edit: I figured it out. I needed a framework. Using pygame now.